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Journal of Cardiovascular Pharmacology and Therapeutics, Vol. 8, No. 4, 253-260 (2003)
DOI: 10.1177/107424840300800402

Atherosclerosis in Type 2 Diabetes Mellitus: The Role of Insulin Resistance

Karol E. Watson, MD, PhD

Division of Cardiology, The David Geffen School of Medicine at UCLA, Los Angeles, Calif; kwatson{at}mednet.ucla.edu

Anne L. Peters Harmel, MD

University of Southern California Keck School of Medicine, Los Angeles, Calif, and the Institute for Insulin Resistance Studies, Durham, NC

Gary Matson, MD

Type 2 diabetes mellitus is associated with a marked increase in the risk of atherosclerotic diseases, including coronary heart disease, peripheral arterial disease, and cerebrovascular disease. Insulin resistance is a key factor in the pathogenesis of type 2 diabetes mellitus. Insulin resistance and its attendant metabolic abnormalities may cause much of the increased cardiovascular risk of type 2 diabetes mellitus. Among the abnormalities associated with insulin resistance are dyslipidemia, hypertension, systemic inflammation, and a prothrombotic state. This review discusses the role that each of these disorders plays in the cardiovascular risk of type 2 diabetes mellitus.

Key Words: atherosclerosis • type 2 diabetes mellitus • insulin resistance


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