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Journal of Cardiovascular Pharmacology and Therapeutics, Vol. 11, No. 4, 256-261 (2006)
DOI: 10.1177/1074248406296108

Effect of Barnidipine on Blood Pressure and Serum Metabolic Parameters in Patients With Essential Hypertension: A Pilot Study

Athanasia Spirou, MD

Evangelos Rizos, MD, DSc

Evangelos N. Liberopoulos, MD, DSc, FASA, FRSH

Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece

Nikolaos Kolaitis, MD, PhD

Hematology Laboratory, University Hospital of Ioannina, Ioannina, Greece

Apostolos Achimastos, MD, DSc

Department of Internal Medicine, Medical School, University of Athens, Athens, Greece

Alexandros D. Tselepis, MD, PhD

Laboratory of Biochemistry, Department of Chemistry, University of Ioannina, Ioannina, Greece

Moses Elisaf, MD, DSc, FASA, FRSH

Department of Internal Medicine, Medical School, University of Ioannina, 451 10 Ioannina, Greece; egepi{at}cc.uoi.gr;vaglimp@yahoo.com

The effect of barnidipine, a calcium channel blocker, on metabolic parameters is not well known. The authors conducted the present pilot study to evaluate the possible effects of barnidipine on parameters involved in atherogenesis, oxidative stress, and clotting activity. This open-label intervention study included 40 adult patients with essential hypertension who received barnidipine 10 mg once daily. Barnidipine significantly reduced systolic and diastolic blood pressure as well as isoprostane levels, which represent a reliable marker of oxidative stress. In contrast, barnidipine had a neutral effect on lipid profile and apolipoprotein levels, did not influence glucose homeostasis, had no effect on renal function, and did not cause any changes in electrolyte levels. Moreover, barnidipine did not affect either the clotting/fibrinolytic status (evaluated by measurement of fibrinogen, total plasminogen activator inhibitor, tissue plasminogen activator, and a2 antiplasmin) or the enzymatic activity of the inflammatory/anti-inflammatory mediators lipoprotein-associated phospholipase A2 and paraoxonase 1, respectively. Barnidipine should be mainly considered as an antihypertensive agent with neutral effects on most of the studied metabolic parameters in hypertensive patients. Any antioxidant effect of barnidipine needs further investigation.

Key Words: barnidipine • hypertension • isoprostane • cholesterol • lipoprotein-associated phospholipase A2 • plasminogen activator inhibitor 1 • paraoxonase • fibrinogen • metabolic parameters


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