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Postconditioning Markedly Attenuates Ventricular Arrhythmias After Ischemia-Reperfusion

Division of Cardiovascular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA; Heart Institute, Good Samaritan Hospital, 1225 Wilshire Boulevard, Los Angeles, CA 90017; rkloner{at}goodsam.org

Joan Dow, BS

Anil Bhandari, MD

Heart Institute, Good Samaritan Hospital, Keck School of Medicine, University of Southern California, Los Angeles, CA

Background: Brief periods of reocclusion (postconditioning) during early reperfusion reduce myocardial infarct size. Whether postconditioning has an effect on lethal ventricular arrhythmias independent of infarction in an in-vivo regional ischemia model is unknown. The purpose of this study was to determine if postconditioning limited reperfusion arrhythmias in a necrosis-free model.

Methods: Anesthetized rats were subjected to 5 minutes of proximal coronary artery occlusion; they were randomized to a control group (n = 15) that underwent reperfusion alone or a postconditioning group (n = 15) that received four cycles of 20 seconds reperfusion, 20 seconds reocclusion before final reperfusion.

Results: During the final reperfusion phase, ventricular arrhythmias occurred in 14 of 15 control rats and 8 of 15 postconditioning rats (P = .017). Ventricular tachycardia occurred in 10 of 15 control rats vs 4 of 15 postconditioning rats (P = .028). Control rats demonstrated 1.3 runs of ventricular tachycardia per minute vs 0.4 runs in postconditioning rats (P = .026). The average duration of ventricular tachycardia runs was 8.8 ± 3.2 seconds in the control group vs 5.0 ± 3.9 seconds in postconditioning rats (P = NS).

Conclusion: This in-vivo study showed that postconditioning markedly attenuates ventricular arrhythmia after regional ischemia in a noninfarct model.

Key Words: ischemia-reperfusion • postconditioning • ventricular tachycardia

Journal of Cardiovascular Pharmacology and Therapeutics, Vol. 11, No. 1, 55-63 (2006)
DOI: 10.1177/107424840601100105


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