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Effects of Low-Dose Atorvastatin on Vascular Responses in Patients Undergoing Percutaneous Coronary Intervention With Stenting

Division of Cardiology, College of Medicine, Konyang University Hospital, Daejeon, South Korea

Eberhard Bassenge, MD, PhD

Institute of Applied Physiology and Balneology, Albert-Ludwigs University, Freiburg, Germany

Ki-Young Kim, MD

Division of Cardiology, College of Medicine, Konyang University Hospital, Daejeon, South Korea

Yi-Chul Synn, MD

Division of Cardiology, College of Medicine, Konyang University Hospital, Daejeon, South Korea

ki-Rack Park, MD

Division of Cardiology, College of Medicine, Konyang University Hospital, Daejeon, South Korea

Michael Schwemmer, MD

Institute of Applied Physiology and Balneology, Albert-Ludwigs University, Freiburg, Germany

Background: The primary endpoint of this study was to evaluate the effects of low-dose atorvastatin on carotid intima-media thickness (IMT) and endothelial function, and the secondary endpoint comprised restenosis and target lesion revascularization (TLR) in patients undergoing percutaneous coronary intervention (PCI) with stenting for the treatment of coronary artery disease.

Methods: Two hundred five consecutive patients (mean age, 60 years) undergoing PCI were prospectively randomized to usual therapy (control group, n = 100) or to 10 mg of atorvastatin daily plus usual therapy (statin group, n = 105). Carotid IMT, endothelial function (flow-mediated dilatation [FMD] of the brachial artery), and coronary angiograms were taken before the study and 6 months after randomization. The 6-month follow-up measurements of the above factors were obtained in 83 patients (83%) of the control group and in 97 patients (92%) of the statin group.

Results: No significant differences were noted in the baseline clinical and angiographic findings in either group. FMD was significantly improved during the 6 months in the statin group (4.38% ± 1.7% vs 4.85% ± 1.6%, P = .003), but did not change in the control group. Carotid IMT did not show any significant changes at 6 months in either group. There was a trend in favor of statin in terms of restenosis rate (26.8% vs 36.1%, P = .177) and TLR rate (18.6% vs 25.3%, P = .274). The changes of FMD were significantly correlated with the changes of total cholesterol and the changes of low-density lipoprotein, respectively (r= -0.336, P = .009, and r = -0.310, P = .046).

Conclusion: Low-dose atorvastatin reduces endothelial dysfunction as measured by FMD, which coincides with the beneficial effects on lipid profiles, and can decrease restenosis and TLR rate in patients undergoing PCI with stenting.

Key Words: statin • endothelial function • restenosis • coronary artery disease

Journal of Cardiovascular Pharmacology and Therapeutics, Vol. 9, No. 3, 185-192 (2004)
DOI: 10.1177/107424840400900306


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