This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Mendoza, C. E. Articles by Rosenberg, D. G. Search for Related Content PubMed PubMed Citation Articles by Mendoza, C. E. Articles by Rosenberg, D. G. Social Bookmarking                         What's this?

Reversal of Refractory Congestive Heart Failure after Thiamine Supplementation: Report of a Case and Review of Literature

Division of Cardiology, University of Miami School of Medicine, Miami, Florida; Division of Cardiology C402, Jackson Memorial Hospital, 1611 NW 12th Avenue, Miami, FL 33136

Francisco Rodriguez, MD

Division of Internal Medicine, University of Miami School of Medicine, Miami, Florida

Donald G. Rosenberg, MD

Division of Cardiology, University of Miami School of Medicine, Miami, Florida

Patients with refractory heart failure comprise a very important subgroup of patients with congestive heart failure. Before assuming that this condition simply reflects advanced, perhaps terminal, myocardial dysfunction, potentially reversible factors should be sought carefully. We describe a 58-year-old Hispanic man with a diagnosis of idiopathic dilated cardiomyopathy who presented with symptoms of severe congestive heart failure, glossitis, and peripheral neuropathy. His hemodynamic profile was characterized by refractory low-output cardiac failure and decreased vascular resistance. Thiamine deficiency was documented by a high thiamine pyrophosphate effect. His clinical condition was quickly reversed with thiamine administration. This response to thiamine administration supports the diagnosis and indicates that thiamine deficiency may play an important etiologic role in the deterioration of cardiac function in some patients with congestive heart failure.

Key Words: thiamine deficiency • congestive heart failure • myocardial dysfunction

Journal of Cardiovascular Pharmacology and Therapeutics, Vol. 8, No. 4, 313-316 (2003)
DOI: 10.1177/107424840300800409


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				J. A. Wooley Characteristics of Thiamin and Its Relevance to the Management of Heart Failure Nutr Clin Pract, October 1, 2008; 23(5): 487 - 493. [Abstract] [Full Text] [PDF]