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Correlation of Angiotensin-Converting Enzyme Gene Polymorphism with Effect of Antihypertensive Therapy by Angiotensin-Converting Enzyme Inhibitor

3rd Medical Building, 7th Floor Department of Medicine, Hebei Provincial People's Hospital, Shijiazhuang 050051, China

Yanmei Du, MD

Department of Analytical Chemistry, Hebei Medical University, Shijiazhuang 050017, China

Yanfang Du, MD

Department of Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang 050071, China

Xizheng Huang, MD

Department of Medicine, Hebei Provincial People's Hospital, Shijiazhuang 050051, China

Background: The correlation of the angiotensin-converting enzyme insertion/deletion polymorphism with essential hypertension shown in previous studies is controversial, and the responses of hypertensive patients with different angiotensin-converting enzyme genotypes to treatment with an angiotensin-converting enzyme inhibitor merits investigation.

Methods: Eighty-nine patients with essential hypertension and 102 normotensive subjects were included in this study. All subjects were genotyped by polymerase chain reaction for the insertion/deletion polymorphism of the angiotensin-converting enzyme gene. Blood pressure was measured before and after taking Benazepril 10 mg, once daily, for 2 months.

Results: The genotype and allele frequencies were similar (X² = 0.64, P = .73; x² = 0.36, P = .55, respectively). The reduction of both systolic and diastolic blood pressure in the DD genotype was significantly greater than in the II genotype (10.13 ± 4.91 vs 5.37 ± 2.79, P < .01; 7.47 + 3.50 vs 4.71 ± 2.40, P < .05, respectively).

Conclusions: No significant association of angiotensin-converting enzyme gene polymorphism with essential hypertension was found. Angiotensin-converting enzyme gene polymorphism might be related to the antihypertensive response to an angiotensin-converting enzyme inhibitor in hypertensive patients.

Key Words: angiotensin-converting enzyme • insertion/deletion polymorphism • polymerase chain reaction • antihypertensive response

Journal of Cardiovascular Pharmacology and Therapeutics, Vol. 8, No. 1, 25-30 (2003)
DOI: 10.1177/107424840300800i105


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