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Journal of Cardiovascular Pharmacology and Therapeutics
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Metalloproteinase in Myocardial Adaptation and Maladaptation

Suresh C. Tyagi, PhD

Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS

Brian D. Hoit, MD

Department of Medicine, Case Western Reserve University, Cleveland OH.

Ventricular remodeling is a compensatory response that comprises the processes of apoptosis, muscle cell hypertrophy, and rearrangement of the extracellular matrix fibers connecting the muscles. These processes are associated with transformation of endothelium and/or fibroblasts to myofibroblasts. Neutral matrix metalloproteinases, membrane type matrix metalloproteinases, and disintegrin metalloproteinase play a significant role in these processes. The cell-extracellular matrix connections are important in maintaining and synchronizing muscle function. However, a complete extracellular matrix-cell disconnect leads to a decrease in muscle cell strength, apoptosis, and hypertrophy.

Key Words: nitric oxide • disintegrin • oxidative stress

Journal of Cardiovascular Pharmacology and Therapeutics, Vol. 7, No. 4, 241-246 (2002)
DOI: 10.1177/107424840200700407
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