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Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) Induced by Amiodarone: A Report on Two Cases

Department of Cardiology, The Heart Institute of Japan; Department of Internal Medicine, Ebara Metropolitan Hospital, Tokyo, Japan

Tsuyoshi Shiga, MD

Department of Cardiology, The Heart Institute of Japan, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku, Tokyo 162-8666, Japan

Toshio Tsushima, MD

Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical University, Japan

Takashi Nirei, MD

Department of Internal Medicine, Ebara Metropolitan Hospital, Tokyo, Japan

Hiroshi Kasanuki, MD

Department of Cardiology, The Heart Institute of Japan

Background: Amiodarone is an effective antiarrhythmic agent for life-threatening arrhythmias but has some noncardiac toxicity. The syndrome of inappropriate antidiuretic hormone secretion (SIADH) induced by amiodarone during long-term therapy seems to be rare among adverse effects.

Subjects and Results: We report on two elderly cases that developed hyponatremia caused by SIADH occurring during the initial loading period of amiodarone therapy. Both cases improved within 3 weeks after reduction of the dose, although amiodarone was continued.

Conclusions: Amiodarone-induced SIADH may occur during the initial loading period, and it may be improved by reduction of the dose without discontinuation of the drug.

Key Words: amiodarone • adverse drug reaction • syndrome of inappropriate antidiuretic hormone secretion (SIADH) • hyponatremia

Journal of Cardiovascular Pharmacology and Therapeutics, Vol. 7, No. 1, 25-28 (2002)
DOI: 10.1177/107424840200700i104


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