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Journal of Cardiovascular Pharmacology and Therapeutics
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HRCT Findings of Amiodarone Pulmonary Toxicity: Clinical and Radiologic Regression

Ludger Wilhelm Poll, MD

Philip May, MD

Jens-Albrecht Koch, MD

Department of Diagnostic Radiology, Heinrich-Heine-University Dusseldorf Dusseldorf, Germany

Gerd Hetzel, MD

Peter Heering, MD

Department of Nephrology and Rheumatology, Heinrich-Heine-University Dusseldorf Dusseldorf, Germany

Ulrich Mödder, MD

Department of Diagnostic Radiology, Heinrich-Heine-University Dusseldorf Dusseldorf, Germany

Amiodarone is an antiarrhythmic drug that can cause interstitial pneumonitis leading to pulmonary fibrosis. A 62-year-old man suffering from atrial fibrillation and recurrent dyspnea was treated with amiodarone. After 15 months of treatment, HRCT revealed bilateral interstitial and alveolar opacifications with high-attenuating pleural-parenchymal consolidations, suggesting amiodarone induced pneumonitis. Three months after cessation of amiodarone treatment, HRCT shows complete regression of pneumonitis. Amiodarone pneumonitis can be misinterpreted and mistreated in patients with further underlying diseases. The present case report demonstrates the diagnostic value of HRCT in the diagnosis of interstitial pneumonitis.

Key Words: high-resolution computed tomography • amiodarone • pulmonary toxicity • pneumonitis

Journal of Cardiovascular Pharmacology and Therapeutics, Vol. 6, No. 3, 307-311 (2001)
DOI: 10.1177/107424840100600311
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