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Comparative Effects of ACE Inhibitors and an Angiotensin Receptor Blocker on Atherosclerosis and Vascular Function

Bo-qing Zhu, MD, FACC

Amanda E. M. Browne, BS

Satyavardhan Pulukurthy, MD

Tony M. Chou, MD, FACC

Division of Cardiology, Department of Medicine, University of California San Francisco, 3rd Floor Philip Block, The Alfred, Commercial Road, Prahran 3181 Australia

Krishnankutty Sudhir, MD, PhD, FRACP, FACC

Alfred Hospital, Hormones and Vasculature Laboratory, Baker Institute, 3rd Floor Philip Block, The Alfred, Commercial Road, Prahran 3181 Australia

Stanton A. Glantz, PhD, FACC

Prakash C. Deedwania, MD, FACC

Kanu Chatterjee, MB, FRCP, FACC

William W. Parmley, MD, MACC

Division of Cardiology, Department of Medicine, University of California San Francisco, 3rd Floor Philip Block, The Alfred, Commercial Road, Prahran 3181 Australia

Background: Both angiotensin-converting enzyme inhibitors (ACE-IS) and angiotensin receptor blockers (ARBS) provide vascular protection. This study was designed to compare ACE-IS with widely differing tissue affinity (captopril and quinapril) and an ARB (losartan) on vascular protection against the adverse effects of high cholesterol.

Methods and Results: Forty-two New Zealand rabbits on a 0.5% cholesterol diet were ran-domized into control, captopril (10 mg/kg/d), quinapril (0.3 mg/kg/d), and losartan (8 mg/kg/d) groups for 14 weeks. Captopril, quinapril, and losartan significantly attenuated aortic lipid lesions (P = 0.001). Captopril and quinapril were more effective than losartan in preserving vascular relaxation.

Conclusions: Captopril, quinapril, and losartan had similar protective effects against atherogenesis. Captopril and quinapril were more effective than losartan in preserving vascular function. Increased bradykinin by ACE inhibition may be responsible for this improved vascular endothelial function.

Key Words: angiotensin-converting enzyme inhibitor • angiotensin receptor blocker • vascular function • atherosclerosis.

Journal of Cardiovascular Pharmacology and Therapeutics, Vol. 6, No. 2, 175-181 (2001)
DOI: 10.1177/107424840100600209


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