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Cost Analysis of Transthoracic Cardioversion of Atrial Fibrillation With and Without Ibutilide Pretreatment

Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI

Bradley P. Knight

Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI

Christian Sticherling

Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI

Michael H. Kim

Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI

Robert L. Baker

Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI

Steven P. Chough

Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI

Kristina Wasmer

Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI

Frank Pelosi, JR

Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI

Gregory F. Michaud

Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI

A. Mark Fendrick

Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI

S. Adam Strickberger

Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI

Fred Morady

Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI

Background: Ibutilide may result in chemical cardioversion of atrial fibrillation and facilitates transthoracic cardioversion by lowering the defibrillation energy requirement. Whether routine pretreatment with ibutilide increases or decreases the cost of cardioversion is unknown. The purpose of this study was to compare the cost of outpatient transthoracic cardioversion of atrial fibrillation with and without ibutilide pretreatment.

Methods: Using a model based on published literature and hospital accounting information, a hypothetical group of 100 patients with atrial fibrillation and a left ventricular ejection fraction >0.30 underwent 2 strategies of outpatient cardioversion: transthoracic cardioversion with and without routine pretreatment with 1 mg ibutilide, and with and without involvement of an anesthesiologist for sedation. If transthoracic cardioversion was unsuccessful in patients who did not receive ibutilide, transthoracic cardioversion was repeated after administration of ibutilide.

Results: If an anesthesiologist was involved, transthoracic cardioversion with ibutilide was associated with incremental cost-savings as the efficacy of ibutilide alone in restoring sinus rhythm increased above the critical values of 20%, 27%, and 35% when the efficacy of transthoracic cardioversion alone was 60%, 80%, and 100%, respectively. In the absence of an anesthesiologist, routine pretreatment with ibutilide increased the cost of cardioversion at all success rates of transthoracic cardioversion.

Conclusions: In the presence of an anesthesiologist, whether or not routine pretreatment with ibutilide lowers the mean cost of cardioversion is determined by the success rates of chemical cardioversion with ibutilide and transthoracic cardioversion. In the absence of an anesthesiologist, ibutilide pretreatment increases the cost of cardioversion.

Key Words: atrial fibrillation • cardioversion • ibutilide.

Journal of Cardiovascular Pharmacology and Therapeutics, Vol. 5, No. 4, 259-266 (2000)
DOI: 10.1054/JCPT.2000.16696


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