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Intravenous Amiodarone in the Management of Atrial Fibrillation

Arrhythmia Service, Cardiology Division, Department of Medicine, Columbia University, College of P & S, Clinical Electrophysiology Service, Columbia Presbyterian Medical Center Campus, of the New York Presbyterian Hospital, New York, NY

Background: Although approved only for therapy of life-threatening ventricular tachy arrhythmias, intravenous amiodarone is also being used for the treatment of atrial fibrilla tion (AF), generally in the intensive care unit setting and most often after cardiac surgery. When used for AF, dosing regimens and clinical experience have varied.

Methods and Results: This article summarizes representative reports in hopes of clarifying the role of intravenous amiodarone for practitioners who prescribe it for the management of AF. The most immediate and most predictable response is reduction of the ventricular rate, which generally is noted after the first 300-400 mg. Restoration of sinus rhythm (car dioversion) may occur, but the precise incidence in a placebo-controlled, blinded study has not been determined. When present, it often takes 24 hours, and a total dose of 1,000 mg or more. Least certain is the efficacy of the drug in preventing the appearance (when used pro phylactically) or reappearance of AF.

Conclusions: More data are required with regard to patient characterization, electrical sys tem status, and dosing regimen to better characterize intravenous amiodarone for this role.

Key Words: antiarrhythmic drugs • supraventricular tachyarrhythmias • cardiac surgery • intensive care unit.

Journal of Cardiovascular Pharmacology and Therapeutics, Vol. 4, No. 4, 199-204 (1999)
DOI: 10.1177/107424849900400401


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