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Journal of Cardiovascular Pharmacology and Therapeutics
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The Effect of Chloroquine on Circulating Platelet Survival in the Rat

Eme Osim

Department of Physiology, University of Zimbabwe

Shepherd Mudzingwa

Department of Physiology, University of Zimbabwe

Cephas Musabayane

Department of Physiology, University of Zimbabwe

Felix Mbajiorgu

Department of Anatomy, University of Zimbabwe

Owen Munjeri

Department of Pharmacy, Faculty of Medicine, University of Zimbabwe, Mt Pleasant, MP167, Harare, Zimbabwe

Background: Chloroquine inhibits platelet aggregation. Because platelet aggregation may lead to the lysis of platelets, the effect of chloroquine administration on circulating platelet survival was studied.

Methods and Results: Platelets harvested from the blood of male inbred (WAG) rats were labeled with 111Indium oxine and returned to other inbred rats. At timed intervals, blood samples were drawn from the rats and taken for radioactivity estimation. In some experi ments, the rats (n = 10) received chloroquine (10 mg/kg) intraperitoneally daily for 3 days. Control rats (n = 10) received normal saline. Indium-labeled platelets disappeared expo nentially in control and test rats. The fraction of indium disappearing/h was significantly less in chloroquine-treated rats than in control rats (0.0368 ± 0.0016 vs 0.0520 ± 0.0016, mean ± SEM; P < .001). In all, 99% of the labeled platelets disappeared in 5.3 days in chloro quine-treated rats and 3.7 days in control rats.

Conclusions: Chloroquine administration increases the life span of circulating platelets in rats. If the results are confirmed in humans, chloroquine may prevent the shortened platelet survival and thrombocytopenia common in malarial infection and other thrombotic disorders.

Key Words: chloroquine • platelet survival.

Journal of Cardiovascular Pharmacology and Therapeutics, Vol. 4, No. 2, 97-102 (1999)
DOI: 10.1177/107424849900400204
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This article has been cited by other articles:


Home page
 J CARDIOVASC PHARMACOL THERHome page
E. Osim, F. Mbajiorgu, I. Nkomo, A. Coutts, O. Munjeri, R. Vaz, S. Arthur, and C. Musabayane
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Journal of Cardiovascular Pharmacology and Therapeutics, January 1, 2000; 5(3): 223 - 228.
[Abstract] [PDF]


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