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Efficacy of Nicardipine for Long-Term Therapy of Chronic Stable Angina

VA Medical Center, Fresno, California

Robert E. Safford

Mayo Clinic, Jacksonville, Florida

Marcus de Wood

Spokane Heart Institute, Spokane, Washington

Dennis Costello

Private Cardiology Practice, LaJolla, California

Steven Goldsmith

Hennepin County Medical Center, Minneapolis, Minnesota

Background: Although angina is a chronic disease, most clinical trials evaluating antiangi nal therapy are of a few weeks or months in duration.

Methods and Results: To evaluate the effects of nicardipine, a second-generation dihydro pyridine calcium channel blocker, as long-term therapy, patients with chronic stable angina were treated for 1 year with open-label nicardipine. Anginal symptoms were controlled with 20 mg tid in 24%, 30 mg tid in 34%, and 40 mg tid in 42%. Of 72 patients completing the 1-year trial, only 14 (19%) had required the addition of long-acting nitrates for control of symptoms. The remaining 57 patients, who had anginal symptoms controlled with nicar dipine alone, were continued into the 3-week, double-blind period and were randomized to continue their usual dose of nicardipine or placebo. Throughout the 1-year, open-label treatment period, the number of anginal episodes and exercise parameters of angina were significantly reduced with nicardipine.

Conclusions: During the double-blind period, the patients who continued on nicardipine had significantly greater exercise time and time to onset of angina than patients who were randomized to placebo. The exercise parameters in the patients randomized to placebo were improved over baseline after 1 year of therapy; however, the improvement with nicar dipine was significantly greater.

Key Words: calcium channel blockers • angina pectoris • coronary artery disease • nicardipine therapy • myocardial ischemia.

Journal of Cardiovascular Pharmacology and Therapeutics, Vol. 3, No. 4, 275-279 (1998)
DOI: 10.1177/107424849800300402


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