This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Açikel, U. Articles by Oto, O. Search for Related Content PubMed Articles by Açikel, U. Articles by Oto, O. Social Bookmarking                         What's this?

Nisoldipine Cardioplegia in the Isolated Rabbit Heart

Department of Thoracic and Cardiovascular Surgery, Dokuz Eylul University, School of Medicine

Eyüp Hazan

Department of Thoracic and Cardiovascular Surgery, Dokuz Eylul University, School of Medicine

Nejat Sariosmanoglu

Department of Thoracic and Cardiovascular Surgery, Dokuz Eylul University, School of Medicine

Hüdai Çatalyürek

Department of Thoracic and Cardiovascular Surgery, Dokuz Eylul University, School of Medicine

Erdem Silistreli

Department of Thoracic and Cardiovascular Surgery, Dokuz Eylul University, School of Medicine

Gül Güner

Department of Biochemistry, Dokuz Eylul University, School of Medicine

Nurten Saydam

Department of Biochemistry, Dokuz Eylul University, School of Medicine

Yeim Tunçok

Department of Pharmacology. Dokuz Eylül University. School of Medicine, Inciralti, Izmir, Turkey

Hülya Güven

Department of Pharmacology. Dokuz Eylül University. School of Medicine, Inciralti, Izmir, Turkey

Özalp Karabay

Department of Thoracic and Cardiovascular Surgery, Dokuz Eylul University, School of Medicine

Oztekin Oto

Department of Thoracic and Cardiovascular Surgery, Dokuz Eylul University, School of Medicine

Background: The metabolic and hemodynamic effects of nisoldipine supplementation in cardioplegia after ischemic injury were investigated in 13 isolated rabbit hearts. Group 1 con sisted of 6 hearts, which received St. Thomas II cardioplegic solution. In group 2, nisoldipine was added to the cardioplegic solution at a concentration of 0.1 mg/kg in 7 hearts.

Methods: The explanted hearts were suspended from Langendorff apparatus and were per fused with Krebs-Henseleit solution. Left ventricular pressure, heart rate, malondialdehyde, glutathione peroxidase, glutathione reductase, reduced glutathione, oxidized glutathione, cre atine kinase MB, (CK-MB), aspartate transaminase, and lactate dehydrogenase (LDH) were measured before and after 60 minutes of ischemia. Peak generated pressure after ischemia was significantly higher in group 2 versus group I while end-diastolic pressure was signifi cantly lower in group 2 after ischemic arrest (P < .05).

Results: Malondialdehyde levels were lower in group 2 (P < .05). Glutathione peroxidase and glutathione reductase levels were significantly higher in group 2 ( P < .05). The only enzymatic significant difference was observed between the preischemic and postischemic levels of aspartate transaminase in group 2 (P < .05).

Conclusions: These findings show beneficial effects of nisoldipine cardioplegia, although its use as a cardioplegic additive is not yet possible. We believe, however, the effects of oral nisoldipine before cardiac surgery can be studied in a clinical setting.

Key Words: nisoldipine • isolated rabbit heart • cardioplegia • myocardial protection.

Journal of Cardiovascular Pharmacology and Therapeutics, Vol. 2, No. 4, 285-290 (1997)
DOI: 10.1177/107424849700200406


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?