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Statins Reduce Appropriate Cardioverter-Defibrillator Shocks and Mortality in Patients With Heart Failure and Combined Cardiac Resynchronization and Implantable Cardioverter-Defibrillator Therapy

Department of Medicine, Cardiology Division, New York Medical College, Valhalla, New York

Wilbert S. Aronow, MD

Department of Medicine, Cardiology Division, New York Medical College, Valhalla, New York, wsaronow{at}aol.com

Fausan S. Tsai, MD

Department of Medicine, Cardiology Division, New York Medical College, Valhalla, New York

Chul Ahn, PhD

Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas

Hoang M. Lai, MD

Department of Medicine, Cardiology Division, New York Medical College, Valhalla, New York

Harshad Amin, MD

Department of Medicine, Cardiology Division, New York Medical College, Valhalla, New York

Kaushang Gandhi, MD

Department of Medicine, Cardiology Division, New York Medical College, Valhalla, New York

William H. Frishman, MD

Department of Medicine, Cardiology Division, New York Medical College, Valhalla, New York

Martin Cohen, MD

Department of Medicine, Cardiology Division, New York Medical College, Valhalla, New York

Carmine Sorbera, MD

Department of Medicine, Cardiology Division, New York Medical College, Valhalla, New York

Of 209 patients with heart failure treated with combined cardiac resynchronization therapy and implantable cardioverter-defibrillator therapy, appropriate cardioverter-defibrillator shocks occurred at 34-month follow-up in 22 of 121 patients (18%) on statins and in 30 of 88 patients (34%) not on statins (P = .009). Deaths occurred in 3 of 121 patients (2%) on statins and in 9 of 88 patients (10%) not on statins (P = .017). Stepwise Cox regression analysis showed that significant independent prognostic factors for appropriate shocks were use of statins (risk ratio = 0.46), smoking (risk ratio = 3.5), and diabetes (risk ratio = 0.34). Significant independent prognostic factors for the time to mortality were use of statins (risk ratio = 0.05), use of digoxin (risk ratio = 4.2), systemic hypertension (risk ratio = 14.2), diabetes (risk ratio = 4.3), and left ventricular ejection fraction (risk ratio = 1.1).

Key Words: cardiac resynchronization therapy • cardioverter-defibrillator shocks • heart failure • statins

This version was published on September 1, 2009

Journal of Cardiovascular Pharmacology and Therapeutics, Vol. 14, No. 3, 176-179 (2009)
DOI: 10.1177/1074248409340157


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