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Journal of Cardiovascular Pharmacology and Therapeutics
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Effects of Different Levels of Cigarette Smoke Exposure on Prognostic Heart Rate and Rate—Pressure-Product Parameters

Martin Unverdorben, MD, PhD

Research, Development & Engineering, Clinical Evaluation, Philip Morris USA, Richmond, Virginia, martin.unverdorben{at}pmusa.com

Anina van der Bijl, MB, ChB

FARMOVS-PAREXEL, Bloemfontein, Republic of South Africa

Linda Potgieter, PhD

FARMOVS-PAREXEL, Bloemfontein, Republic of South Africa

Cornea Venter, BSC Hon

FARMOVS-PAREXEL, Bloemfontein, Republic of South Africa

Sagar Munjal, MD

Research, Development & Engineering, Clinical Evaluation, Philip Morris USA, Richmond, Virginia

Qiwei Liang, PhD

Research, Development & Engineering, Clinical Evaluation, Philip Morris USA, Richmond, Virginia

Bernhardt Meyer, MD, PhD

FARMOVS-PAREXEL, Bloemfontein, Republic of South Africa

Hans-Jürgen Röthig, MD, PhD, FCP, FFPM

Research, Development & Engineering, Clinical Evaluation, Philip Morris USA, Richmond, Virginia

Reduced cigarette smoke exposure in adult smokers switching from a conventional cigarette (CC) to a potential exposure-reduced electrically heated cigarette smoking system (EHCSS) and no smoking (NS) improved exercise performance. The effects of reduced smoke exposure on the prognostic parameters heart rate (HR) and rate—pressure-product (RPP) were investigated. A total of 18 male adult CC-smokers were randomized in a 3-period cross-over study to CC, EHCSS, or to NS for 3 days each before performing spiroergometry. Exposure parameters declined from CC to EHCSS and to NS. Resting HR and RPP increased from NS to EHCSS and to CC. Chronotropic response/HR recovery were more pronounced in NS than in EHCSS and CC. RPPmax was similar in NS and EHCSS and lowest during CC. Reduced tobacco smoke exposure for 3 days improved the prognostic parameters HR and RPP in an apparently dose-dependent manner.

Key Words: reduced exposure • smoking • heart rate • chronotropic response • heart rate recovery • rate-pressure-product

This version was published on September 1, 2008

Journal of Cardiovascular Pharmacology and Therapeutics, Vol. 13, No. 3, 175-182 (2008)
DOI: 10.1177/1074248408321571
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