Journal of Cardiovascular Pharmacology and Therapeutics

 

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This version was published on June 1, 2008
Journal of Cardiovascular Pharmacology and Therapeutics, Vol. 13, No. 2, 89-93 (2008)
DOI: 10.1177/1074248408316485

Intracoronary Abciximab Use in Patients Undergoing PCI at a Community Hospital: A Single Operator Experience

Sandeep S. Patel, MD

Department of Cardiology, Mt. Sinai Medical Center/Bronx VA, Bronx, New York

Hiralal Rana, MD

Department of Cardiology, Mt. Sinai Medical Center/Bronx VA, Bronx, New York

Daniel A. N. Mascarenhas, MD, FACC, FSCAI

Department of Medicine, Easton Hospital, danmasc{at}rcn.com, Division of Cardiology Easton Hospital, Easton, Pennsylvania, Drexel University, Philadelphia, Pennsylvania

Objective: To evaluate the safety of intracoronary (IC) abciximab during percutaneous coronary intervention (PCI). Background: Adjunctive treatment with glycoprotein IIb/IIIa inhibitors, especially abciximab, during PCI has been shown to improve clinical and procedural outcomes in numerous studies. However, significant bleeding complications exist with its use and this has limited its standard use. Interest has grown in local (IC) use with studies showing safety and long-term effectiveness, especially in patients with high thrombus loads. Methods: A retrospective review of records in a database of patients who had PCI by a single operator at the Easton Hospital. Results: 611 patients received IC abciximab, and there were no complications in 610 (98.3%) patients; only 1 had an allergic reaction. Conclusions: IC abciximab is safe and has a unique role in the catheterization lab and in patients at high risk of bleeding complications who would benefit from its limited use.

Key Words: percutaneous coronary intervention (PCI) • glycoprotein IIb/IIIa inhibitors • abciximab • acute coronary syndrome


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