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Journal of Cardiovascular Pharmacology and Therapeutics
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Effect of Selective Serotonin Reuptake Inhibitors on Cardiovascular Morbidity and Mortality

Abby E. Von Ruden, PharmD

College of Pharmacy, University of Minnesota

David E. Adson, MD

Department of Psychiatry, University of Minnesota

Michael Kotlyar, PharmD

College of Pharmacy, University of Minnesota, kotly001{at}umn.edu, Department of Psychiatry, University of Minnesota, Department of Experimental and Clinical Pharmacology University of Minnesota, Minneapolis., Minnesota

Depression in patients with coronary artery disease is associated with increased cardiovascular morbidity and mortality. It is not clear, however, if treatment with selective serotonin reuptake inhibitors (SSRIs) decreases the rate of future cardiovascular events. This paper reviews the available literature regarding the effect of SSRI use on cardiovascular outcomes. Thirteen studies addressing this issue were identified. Of these, 5 concluded that SSRI use is associated with decreased cardiovascular morbidity or mortality, 2 concluded that SSRI use was associated with worsened prognosis, and 6 studies found no statistically significant association. Almost all of the published literature examining the effect of SSRIs on cardiovascular outcomes is based on observational studies, thereby precluding definitive conclusions. Randomized controlled studies are clearly needed to definitively address this issue.

Key Words: serotonin uptake inhibitors • depression • coronary artery disease

Journal of Cardiovascular Pharmacology and Therapeutics, Vol. 13, No. 1, 32-40 (2008)
DOI: 10.1177/1074248407308467
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