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Dose-Dependent Effect of Rosuvastatin Treatment on Urinary Protein Excretion

Department of Internal Medicine, School of Medicine, University of Ioannina, Greece

Haralampos J. Milionis, MD

Department of Internal Medicine, School of Medicine, University of Ioannina, Greece

Vasilios G. Saougos, MD

Department of Internal Medicine, School of Medicine, University of Ioannina, Greece

Konstantinos G. Lagos, MD

Department of Internal Medicine, School of Medicine, University of Ioannina, Greece

Christine Kostara, PhD

Laboratory of Clinical Chemistry, School of Medicine, University of Ioannina, Greece

Eleni T. Bairaktari, PhD

Laboratory of Clinical Chemistry, School of Medicine, University of Ioannina, Greece

Moses S. Elisaf, MD

Department of Internal Medicine, School of Medicine, University of Ioannina, Greece, egepi{at}cc.uoi.gr

Concerns have been raised because of observations of proteinuria associated with rosuvastatin treatment. In this open-label study, a potential dose-dependent effect was investigated of rosuvastatin on urinary protein excretion and renal function parameters in 90 hyperlipidemic patients randomly assigned to rosuvastatin 10 mg/day (n = 45) or 20 mg/day (n = 45). Urinary samples were collected from patients and 40 age- and gender-matched controls to determine electrolyte, uric acid, creatinine, and protein (total, albumin, IgG, and 1-microglobulin) levels at baseline and after 12 weeks. A dose-dependent increase in the excretion of 1-microglobulin (17.6% in rosuvastatin 10 vs 34.9% in rosuvastatin, 20 mg/day; P = .03 for the comparison between groups) was observed. A trend toward an increase in the estimated glomerular filtration rate was noted in only patients receiving 20 mg/day of rosuvastatin. These findings indicate that rosuvastatin treatment increases the urinary excretion of 1-microglobulin urinary excretion in a dose-dependent manner without adversely affecting renal function.

Key Words: 1-microglobulin • dose-dependent effect • proteinuria • renal function • rosuvastatin

Journal of Cardiovascular Pharmacology and Therapeutics, Vol. 12, No. 4, 292-297 (2007)
DOI: 10.1177/1074248407306676


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