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Journal of Cardiovascular Pharmacology and Therapeutics, Vol. 12, No. 3, 213-219 (2007)
DOI: 10.1177/1074248407304749

Cardiovascular and Endothelial Effects of Fish Oil Supplementation in Healthy Volunteers

Atman Prabodh Shah, MD

David Geffen School of Medicine at UCLA, Harbor-UCLA Medical Center, Torrance, apshah73{at}yahoo.com

Anne Marie Ichiuji, MD

Kaiser Permanente Medical Center, Division of Cardiology, Los Angeles California

Janet K. Han, MD

Greater Los Angeles VA Healthcare

Mahmoud Traina, MD

UCLA-Olive View Medical Center Sylmar

Adel El-Bialy, MD

UCLA-Olive View Medical Center Sylmar

Sheba Kamal Meymandi, MD

UCLA-Olive View Medical Center Sylmar

Robin Yvonne Wachsner, MD

UCLA-Olive View Medical Center Sylmar

Consumption of fish oil (FO) is associated with reduced adverse cardiovascular events. In a randomized, blinded, placebo-controlled trial, 26 subjects (17 men and 9 women; mean age [± SD] 31 ± 3.7 years) received 1 g FO capsule (n = 14) or placebo (1 g of corn oil, n = 12) for 14 days. At day 0 and day 14, heart rate (HR), blood pressure, endothelium-dependent brachial artery flow-mediated vasodilation (EDV), and endothelium-independent nitroglycerin-mediated vasodilation (EIDV) were assessed with ultrasound. FO supplementation resulted in a significant increase in EDV (20.4% ± 13.2% vs 9.9% ± 5.4%; P = .036) and EIDV (32.6% ± 16.8% vs 18.0% ± 14.9%; P = .043). Resting HR decreased by a mean of 5.9 ± 9.4 bpm (FO) compared with placebo (mean increase of 0.73 ± 4.8 bpm [P = .05]). FO supplementation in healthy subjects is associated with improved endothelial function and decreased resting HR.

Key Words: endothelium • fish oil • hemodynamics


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