This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Wadhani, N. Articles by Gaud, C. Search for Related Content PubMed PubMed Citation Articles by Wadhani, N. Articles by Gaud, C. Social Bookmarking                         What's this?

Dose-Dependent Effects of Oral Dronedarone on the Circadian Variation of RR and QT Intervals in Healthy Subjects: Implications for Antiarrhythmic Actions

David Geffen School of Medicine at University of California, Los Angeles, and VA Greater Los Angeles Healthcare System, Los Angeles, California

Jonnalagedda SM Sarma, PhD

David Geffen School of Medicine at University of California, Los Angeles, and VA Greater Los Angeles Healthcare System, Los Angeles, California

Bramah N. Singh, MD, PhD, DSc

David Geffen School of Medicine at University of California, Los Angeles, and VA Greater Los Angeles Healthcare System, Los Angeles, California, bsingh{at}ucla.edu

David Radzik, MD

Sanofi-Aventis, Chilly-Mazarin, France

Christine Gaud, MD

Sanofi-Aventis, Chilly-Mazarin, France

Dronedarone, a non-iodinated benzofuran derivative, was developed as a potentially less toxic alternative to amiodarone. This study describes Holter data of dronedarone in humans. Five groups of healthy subjects were given 1 of 5 oral doses of dronedarone in a twice-daily regimen or placebo. Holter recordings of circadian rhythmicity of RR and QT intervals were evaluated. Dronedarone prolonged RR and QT intervals as a function of dose, without effect on circadian patterns. The relative prolongation of QT, QTc, and RR by dronedarone was significant. The QTc interval did not exhibit a clearly recognizable circadian pattern, suggesting that the circadian pattern of the QT interval was mostly a reflection of circadian changes in the RR interval in the study population. Dronedarone resembled amiodarone in class III and sympatholytic effects, indicating its potential as a unique antiarrhythmic compound seemingly devoid of the side effects mediated by iodine in amiodarone.

Key Words: dronedarone • QT circadian rhythm • antiar-rhythmic agent

Journal of Cardiovascular Pharmacology and Therapeutics, Vol. 11, No. 3, 184-190 (2006)
DOI: 10.1177/1074248406290678


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				B. N. Singh, S. J. Connolly, H. J.G.M. Crijns, D. Roy, P. R. Kowey, A. Capucci, D. Radzik, E. M. Aliot, S. H. Hohnloser, and the EURIDIS and ADONIS Investigators Dronedarone for Maintenance of Sinus Rhythm in Atrial Fibrillation or Flutter N. Engl. J. Med., September 6, 2007; 357(10): 987 - 999. [Abstract] [Full Text] [PDF]