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Comparison of Pyrroloquinoline Quinone and/or Metoprolol on Myocardial Infarct Size and Mitochondrial Damage in a Rat Model of Ischemia/Reperfusion Injury

Cardiology Section, VA Medical Center, Department of Medicine, University of California, San Francisco

Ursula Simonis, PhD

Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, California

Gary Cecchini, PhD

Molecular Biology Division, VA Medical Center, Department of Biochemistry and Biophysics, University of California, San Francisco

Hui-zhong Zhou, MD

Cardiology Section, VA Medical Center, Department of Medicine, University of California, San Francisco

Luyi Li, MD

Cardiology Section, VA Medical Center, University of California, San Francisco

John R. Teerlink, MD, FACC

Cardiology Section, VA Medical Center, Department of Medicine, University of California, San Francisco

Joel S. Karliner, MD, FACC

Cardiology Section, VA Medical Center, Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, joel.karliner{at}med.va.gov

The cardioprotective effectiveness of low-dose pyrroloquinoline quinone (PQQ, 3 mg/kg) was compared with metoprolol, a ß₁-selective adrenoceptor antagonist. Rats underwent 30 minutes of left anterior descending coronary artery occlusion and 2 hours of reperfusion. Metoprolol and/or PQQ were given at the onset of reperfusion to mimic clinical treatment. Metoprolol and/or PQQ reduced infarct size and protected against ischemia-induced left ventricular dysfunction after 2 hours of reper-fusion. Combined therapy augmented left ventricular developed pressure at the end of reperfusion. Metoprolol or PQQ alone enhanced mitochondrial respiratory ratios in ischemic and nonischemic myocardium. Although the PQQ/metoprolol combination therapy increased respiratory ratio values, the effects were small when compared with PQQ alone. Only PQQ decreased lipid peroxidation. Metoprolol and/or PQQ given at the onset of reperfusion reduce infarct size and improve cardiac function. Combination therapy further reduces infarct size. PQQ is superior to metoprolol in protecting mitochondria from ischemia/reperfusion oxidative damage

Key Words: pyrroloquinoline quinone • metoprolol • ischemia/reperfusion

Journal of Cardiovascular Pharmacology and Therapeutics, Vol. 11, No. 2, 119-128 (2006)
DOI: 10.1177/1074248406288757


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