This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Papadopoulos, D. P. Articles by Papademetriou, V. Search for Related Content PubMed PubMed Citation Articles by Papadopoulos, D. P. Articles by Papademetriou, V. Social Bookmarking                         What's this?

Resistant Hypertension: Diagnosis and Management

Hypertension and Cardiovascular Research Clinic, Georgetown University/VAMC, Washington, DC, papavip{at}aol.com

Vasilios Papademetriou, MD

Hypertension and Cardiovascular Research Clinic, Georgetown University/VAMC, Washington, DC

The incidence of resistant hypertension, the failure to reduce blood pressure below 140/90 mm Hg, despite the use of 3 antihypertensive medications at optimal doses including a diuretic, is estimated to be less than 5% of the hypertensive population. Resistant hypertension increases the risk of stroke, myocardial infarction, congestive heart failure, and renal failure. Evaluation of the patient with resistant hypertension should include 24-hour ambulatory blood pressure monitoring or home measurements and a limited search for secondary causes. Treatment should focus on optimizing the drug regimen in a logical way, based on the patient’s comorbidities and tolerability. Long-acting, well-tolerated once-daily medications are preferred, and the regimen should include in sequence a diuretic, ß-blocker, angiotensin-converting enzyme/angiotensin receptor-blocker inhibitors, and a calcium-channel blocker. This article reviews the definitions and causes and provides specific recommendations for the evaluation and management of patients with this life-threatening condition

Key Words: resistant hypertension • etiology • therapy

Journal of Cardiovascular Pharmacology and Therapeutics, Vol. 11, No. 2, 113-118 (2006)
DOI: 10.1177/1074248406289735


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				D. P. Papadopoulos and V. Papademetriou Low-dose Fixed Combination of Bisoprolol/Hydrochlorothiazide as First Line for Hypertension: A Review of the Rationale and Clinical Evidence Angiology, October 1, 2009; 60(5): 601 - 607. [Abstract] [PDF]

				D. P. Papadopoulos and V. Papademetriou Metoprolol Succinate Combination in the Treatment of Hypertension Angiology, October 1, 2009; 60(5): 608 - 613. [Abstract] [PDF]