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Journal of Cardiovascular Pharmacology and Therapeutics
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Prevention of Restenosis by Local Drug Delivery

Raj R. Makkar, MD

Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles. CA 90018-1865.

Neal Eigler, MD

Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles. CA 90018-1865.

Frank Litvack, MD

Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles. CA 90018-1865.

James S. Forrester, MD

Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles. CA 90018-1865.

Local drug therapy for preventing restenosis after angioplasty has been investigated for over a decade. Biologically active agents ranging from drugs to genes can be delivered locally using a wide variety of catheters. Microspheres, liposomes, and polymers have been used to enhance drug retention at the delivery site. More recently stents have been investigated as devices to attain local drug delivery, either by coating with polymers, seeding with genetically modified cells or by using them as a source of local radiation. Though the best method of delivering agents locally remains undefined, this approach is likely to emerge as an essential mode of therapy in the near future.

Key Words: balloon angioplasty • stents • biopolymer • microspheres.

Journal of Cardiovascular Pharmacology and Therapeutics, Vol. 1, No. 2, 177-188 (1996)
DOI: 10.1177/107424849600100212
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